A Caspase-Related Protease Regulates Apoptosis in Yeast
نویسندگان
چکیده
منابع مشابه
Cleavage of Mcd1 by caspase-like protease Esp1 promotes apoptosis in budding yeast.
Over the last decade, yeast has been used successfully as a model system for studying the molecular mechanism of apoptotic cell death. Here, we report that Mcd1, the yeast homology of human cohesin Rad21, plays an important role in hydrogen peroxide-induced apoptosis in yeast. On induction of cell death, Mcd1 is cleaved and the C-terminal fragment is translocated from nucleus into mitochondria,...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2002
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(02)00501-4